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[quote=Anonymous][quote=Anonymous]Thanks, 11:47!  It's definitely been the worst run of bad medical luck for our family. I don't have any history of immune issues, nor does anyone in my family. Luckily I am pretty healthy overall- I don't even take anything besides prenatal vitamins and the usual fish oil, Vit D, etc! The stress of the cancer fight has made me put on about 20 pounds, though. My husband has cancer and also Crohn's disease, so there could arguably be something "there" in the frozen sperm, but I don't know how that translates to arrested embryos once transferred to me. Our child is male, and I have read on this board and others about "anti-male" antibodies that your body can create... not sure if that's a real thing. I could not find anything on Dr. Braverman's site about local partners, but I have read that SIRM does do some immune testing/investigation, and they have a clinic location in Dallas, so I will call them. [/quote]

New PP here.  I'm in a similar situation, pregnant easily and right away with a son, then started TTC #2 right away, it's now been 35 cycles and I've never been pregnant a second time.  I was also found to have "immune issues"--I have no health problems, no history of autoimmune issues in the family, etc.  My RE said that I have the anti-Y chromosome antibodies from having a firstborn male, and that this is preventing implantation to the point where I've never even had a chemical pregnancy.  At first it sounded crazy to me, but now it all makes sense why I haven't had a single BFP in 35 cycles (also did infertility treatments but not immune treatments).  I was diagnosed as "unexplained" by 5 other REs.

Also, I've noticed that nearly everyone I've talked to experiencing unexplained, long-term secondary infertility has a son as their first child.  Just an observation, but I find that interesting, I personally think this anti-Y chromosome antibody thing is way more common that we think and accounts for a lot of unexplained secondary infertility problems.[/quote]

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