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[quote=Anonymous][quote=Anonymous][quote=Anonymous][quote=Anonymous]Is it absolutely certain that pfizer will give 5-11 yr olds 10 mcg? Or is it a good chance they will stick with the 30mcg dose like for everyone else so far? Because there is so much more data for that dose?  Has there been any evidence that the 5-11 yr olds already in the trial who got the 30 mcg did poorly? I thought the myocarditis was just in older than 12yr old boys?  [/quote]

We don't have data for younger kids yet.  But for older individuals, yes, the 12-17 year-old-boy demographic had the highest observed frequency of myocarditis and pericarditis, estimated at &lt;70 cases per million second doses.  Though, that should probably be taken with a grain of salt.  When the VRBPAC discussed this, they noted that it doesn't take much to come back with a finding of myocarditis if you go out looking for one.  So, if they looked harder for it in kids, of course they'd find a lot more there.

And yes, the Pfizer phase 2/3 trials used 10mcg in the 5-11 group, and 3mcg in the &lt;5 group.  [/quote]

nobody was “looking” for the myocarditis - these kids were presenting with chest pain to the ER. And we have no idea what the long-term impacts are of it. [/quote]

Really?  I've gone to the doctor before with chest pain.  Do you know how often I've gotten a cardiac MRI?  Never.  Most cases would never get diagnosed.  But they started doing more cardiac MRIs when reports of myocarditis started coming out, and the cardiac MRI is a much more sensitive instrument than an ECG or echo, or just trying to diagnose off of symptoms.

And while it is technically true that we don't know what the long-term impacts are, that's a very different statement than saying we have reason to actually be worried about long-term impacts.

[/quote]

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