Reply to "mild" PCOS, do i need metformin? insulin resistance?

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Reply to ""mild" PCOS, do i need metformin? insulin resistance?"

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[quote=Anonymous][quote=Anonymous]I'm seeing an immunologist (Braverman), and he originally suspected PCOS, although I don't really have any signs and actually have a low AMH and moderate AFC. Normal periods. And then my fasting blood work came back normal too. Still he has me of Metformin, and quite a high dose, to help with egg quality. I think it's standard with all his patients, PCOS or not. I'd take it if I were you.[/quote]

Interesting you mention this. I am also seeing an immunology-inclined RE (Abbasi) and she also suspected PCOS based on my long cycles, somewhat high AMH, and probably my weight though she didn't say so specifically. But other than the irregular cycles (32-45 days but always ovulating), high AMH, and lots of eggs seen on a scan, I didn't have any of the factors. All my hormone tests came back normal, my ovaries don't have the pearl thing, and I wasn't even insulin resistant. She put me on Metformin anyway. After a week of that we did IUI with letrozole and I am now 11 weeks pregnant (and taking a ton of immune and clotting-related drugs). Her view was that Metformin would help control the environment around the egg -- my issue was that I kept getting pregnant in cycles where I ovulated very late and then I would miscarry. She thought the Metformin and letrozole together would fix that. Haven't had the genetic testing yet so we'll see if it worked.

My OB agrees that Metformin can't hurt and may help, even if you don't have a formal PCOS diagnosis. Might be worth it to try.[/quote]

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