Reply to Considering IVF with PGD after two trisomies

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[quote=Anonymous]Hi, OP. I responded to your thread over in the expectant/postpartum moms forum. First of all, I'm so, so sorry you are going through this.

My DW TFMR with a T21 pregnancy in early 2015. Since then she's had one failed FET (with a PGS normal embryo), and two miscarriages (one was allegedly normal because we tested the tissue but that's still questionable because they didn't do microarray) and the second m/c baby had Turner syndrome.

After TFMR, we panicked and had our one frozen embryo (from that same batch) thawed, tested, and frozen, thawed, and transferred. It was normal. We are convinced that the extra thaw/freeze is what made it not stick.

After that DW couldn't get anything to day 5 so there was nothing to biopsy and nothing to freeze. We tried for at least two cycles and nothing. At that point we switched clinics and began working with Dr. Davis at Cornell who suggested forsaking the testing and doing a day 3 fresh transfer. We took his advice twice and she got pregnant both times, which both resulted in aforementioned m/c.

DW is now a patient with Dr. Braverman because we suspect there are immune issues. Interestingly she will be treated with lots of different drugs, and she did have a laparoscopy to treat suspect (and confirmed) endometriosis, but Dr. Braverman said no to PGS testing. He wants her to do an FET and only use what we freeze, but said do not touch those embryos despite the fact that 2/3 losses were chromosomally abnormal.

A couple of questions. Have you and your husband done any sort of genetic testing? Have you discussed this with a genetic counselor? And have you considered seeing a MFM doctor - Dr. Hammersley in Rockville is a good one. DW has already consulted with her and, god willing, if DW gets pregnant, she'll be working with her.

Unless you and DH have some sort of genetic incompatibility issue, I'd try at home again. Chances of two T21 pregnancies are so rare without genetic predisposition, so I can't imagine what chances are of a third T21 pregnancy (although I totally get that numbers/odds mean nothing when you have gone through this).

PGS can certainly rule out chromosomally abnormal embryos, but as you know, IVF is costly, time consuming, and emotionally draining. I can't imagine being where you are emotionally and staring down the prospect of IVF. It's daunting for anyone.

So step one should be genetic testing/counseling to get more specific information so that you can decide on next steps. IVF is f-ing hard, but if you truly want another child, you can do it. You can lean on each other for support and hopefully, one day, this will be less painful. It will never go away, and it will forever change the fabric of the narrative that is your life - but hopefully it will become easier.

We have one healthy child, and I understand the desire to want to complete your family in the way that feels right for you. When people (namely DW and my own family) tell us we should just be happy with one healthy child, it's so difficult because they are not in our shoes and they do not understand. But they mean well.

Good luck, OP. My DW will likely chime in with her own advice as well as some suggestions for supplements that might help with egg quality. I'll be thinking of you and wishing you luck and peace.

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