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[quote=Anonymous]I have a 10 year old ASD son (HFA) with severe anxiety and significant OCD and repetitive behaviors.  Tried three antidepressants (including SNRI's) and all were activating as you describe.  Both our psychiatrist and pediatrician say that Prozac is the most activating, disinhibiting, and worsens anxiety, especially in ASD kids.  We now are trying a mini dose of lexapro and after only two weeks it is making a big difference in phobias and social anxiety in general.  When it works, lexapro is considered one of the "cleanest" ssri's with respect to side effects (but again, everyone can have a different reaction to any of these.

I completely understand your frustration with meds, though.  My DS had severe comorbid anxiety his whole life (and it was at it's worst at 6) and we just this year started trying meds as a last resort.  Once you go through three or four that don't work and/or make it worse, it's difficult to remain optimistic about med therapy.  We almost gave up.  But, it really is about finding the right match and to be fairly certain that you are dealing with the correct diagnosis.  For instance, adhd meds can be terribly activating if the child does not have ADHD (and both ASD and severe anxiety can mimic certain ADHD symptoms).  For us, lexapro seems to be the med that agrees with my DS (at least for now) so that he can be more amenable to therapy.  Unfortunately, there's a lot of trial and error before you hit on the right one.  Best of luck.[/quote]

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