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Infertility Support and Discussion
Reply to "Why are high stims bad for low ovarian reserve? "
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[quote=Anonymous][quote=Anonymous]This is still being studied but I believe the current theory is that anti-Mullerian hormone (AMH), LH, testosterone, and E2 are significantly higher in follicles from a natural cycle than in stimulated IVF follicles whereas FSH is significantly lower. This suggests an alteration of the follicular metabolism in stimulated cycles. Here's a paper that compared hormone levels in the follicular fluid from NC-IVF and conventional IVF http://www.ncbi.nlm.nih.gov/pubmed/24608520 However, here is a paper that compared the number of live births from women under 35 who had normal ovarian reserves and it found no difference between mild stimulation and conventional stimulation. http://www.ncbi.nlm.nih.gov/pubmed/26524799 [/quote] From the second paper: "For aged ? 35 there were no differences in pregnancy rates per transfer but a trend for higher pregnancy rates per retrieval with conventional stimulation. [b]For all other age groups both pregnancy rates per transfer and retrieval were significantly higher with conventional stimulation.[/b] This was reflected with a higher average number of babies born per retrieval with conventional." In other words, women over the age of 35 who had good ovarian reserves had higher success rates with conventional IVF. Also, the authors noted that more than one pregnancy can be achieved with conventional IVF through freezing embryos. [/quote]
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