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[quote=Anonymous]I found out that I have MTHFR C677T (double mutation) when my naturalist doctor went on a hunch and had me basically tested for Cholesterol levels (it was part of that series of blood tests, which he knew and which he was aiming to test me for). He had the hunch because I had been dealing with depression and anxiety for years. Never had trouble getting pregnant (did successfully once so far). Anyway, to get to the point: He gave me a formulated B-complex vitamin that basically gave me astronomical levels of ACTIVE Folate (which I think is B-6) and B-12 which I had to take daily and consistently. I discovered however, as some people do, that B-12 really hypes me up and I get very edgy and anxious when I take that much (over a thousand times the daily value percentage). Please let me emphasize, this gene mutation is a deficiency in the body's ability to produce ACTIVE folate, not the regular folate or folic acid that you get from the average B-complex or prenatal or multi-vitamin. The body normally takes folate we consume in food or vitamin form and transforms it with the methylenetetrahydrofolate reductase enzyme, but in this gene mutation, this enzyme is not produced in sufficient forms to keep active folate in sufficient levels. There's more to that which leads to blood clots and miscarriage that has to do with Homocysteine (another amino acid) levels.

Whew! So what I'm trying to say is that I eventually found several brands of vitamins that make just active folate (or 5-Methyl tetrahyrdo folate) which is trademarked as "Quatrefolic". I currently take "Doctor's Best Active Folate" because they basically have the best deals for the right product. You can get active folate at some natural food stores, but I found it easiest at the Vitamin Shoppe, which is all over the US. It costs about $11 for 90 pills of 400mcg of active folate alone per pill. No other additives. I take 3 pills of 400mcg a day, no less. I don't intend this to be medical advice, I just know that without it, I cannot function. Please consider talking with an internal doctor about options for active folate. Know that if you get hyper on B-12 you are not alone and you have options. Anyway, Good luck![/quote]

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