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Trying to Conceive (TTC)
Reply to "confused- what do you think about my situation? and why don't they just use progesterone?"
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[quote=Anonymous]And another- I think this is more broadly about pregnancy viability since it mentions diff. b/t mc and ectopic - but I'd be interested in others; interpretations: https://www.ebmedicine.net/topics.php?paction=showTopicSeg&topic_id=130&seg_id=2558 Progesterone Serum progesterone levels provide an additional or alternative marker to determine which patients need further evaluation and follow-up for possible ectopic pregnancy.39,40 Progesterone levels can be problematic since they are not universally available in a timely manner and are not accurate enough in isolation to diagnose ectopic pregnancy. However, a single value that is very high or very low can be helpful. In a prospective study of 700 patients, a progesterone level greater than 22 ng/mL reliably (99% accuracy) excluded the diagnosis of ectopic pregnancy.39 However, lower progesterone levels have a positive predictive value of only 18%. Very low levels of progesterone (less than 5 ng/mL) can reliably exclude a viable intrauterine pregnancy but do not differentiate miscarriage from an ectopic pregnancy.38 In a hypothetical cohort study based on test characteristics to evaluate diagnostic strategies, the use of progesterone alone resulted in a miss rate of 2.5%, which was felt to be clinically unacceptable.41 Therefore, progesterone should not be used alone unless it is over 22 ng/mL and only in conjunction with sonography. [/quote]
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