Reply to When doctors say that GLP-1’s are for a lifetime

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[quote=Anonymous][quote=Anonymous]What do they mean?

I have a relative with psychosis that responds well to medication.  However they are very distressed about medication related weight gain, and weight related side effects.  Their doctor is willing to prescribe GLp-1’s and this stage in life I can help with the logistics but they are much younger than me so obviously I can’t guarantee to help forever.  What happens if someone goes off?  Does it just go back to before or is there something worse to worry about?[/quote]

At this point it is pretty clear that when people go off of a GLP1 they gain the weight back. As to whether or not there is something "worse to worry about," we just don't know yet -- but I think there is a good chance we will see that those who go on a GLP1 and then go off of it have damaged their metabolism and gain more weight back than they lost. We just don't know yet.

FWIW, I have a mental illness and gained almost 90 pounds due to psych medication (this was over a period of several years, then I lived with it for many years). I was always naturally very skinny and psych meds (I have taken a variety of them over the years, the real bad ones are the 2GAs) just wrecked my metabolism and eventually my body (obesity, severe obstructive sleep apnea, arthritis, low self esteem and low quality of life, etc, etc). I have been on Wegovy for a little over a year and a half and am down to a "normal" bmi. I'm very glad, but it hasn't been an easy time of it (the side effects have been bad -- not only GI stuff but debilitating fatigue).

I feel like it's a horrible game of dominoes ... take this med but it causes this bad thing ... so now take this med to address that ... and so on and on. But if you need them, you need them. And I do. I will say that I'm heartened at least by the fact that psychiatry is finally publicly recognizing how serious the weight gain is (for most of the time I've been on psych meds, the side effect of weight gain was treated as a vanity concern but the reality is that it is almost certain to significantly shorten most of our lives).

Hope this helps. [/quote]

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