Reply to Son, 20, first signs of bipolar

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[quote=Anonymous][quote=Anonymous][quote=Anonymous]First, book an appointment with the doctor. There is increasing evidence that bipolar disease is a physical disease caused by an autoimmune response, possibly to the Epstein-Barr Virus, Lupus or some other autoimmune diseases.

See here: https://health.ucdavis.edu/news/headlines/autoimmune-disease-or-psychotic-disorder/2025/04
https://onlinelibrary.wiley.com/doi/full/10.1002/cti2.1116v
https://www.managedhealthcareexecutive.com/view/autoimmune-diseases-almost-double-mental-health-disorder-risk

Take your son in for a comprehensive checkup, noting your concerns about autoimmune diseases and/or inflammation. Do you have autoimmune diseases in your family? Do you see other signs of autoimmune disease? Does he have vivid dreams or nightmares? [/quote]

Those do not say that bipolar disorder is caused by autoimmune diseases. The links say that many people with autoimmune diseases experience neuropsychiatric symptoms, and for some even symptoms of psychosis. The last one also says that people with autoimmune disease have increased risk of a psychiatric comorbidity. [/quote]

One important clue to the likelihood of BD being an autoimmune disease comes from the observations that, like multiple sclerosis (MS), which is a chronic autoimmune disease of the central nervous system (CNS), BD tends to present clinically in adolescence and early adulthood and that it initially has a relapsing–remitting course, which later becomes progressive and unremitting.14 Intrathecal IgG synthesis, a hallmark of MS, occurs in 30% of patients with BD compared with 4% of controls,15 as well as in healthy siblings of MS patients.16 It has been hypothesised that intrathecal IgG synthesis with oligoclonal bands is caused by clonal expansion of EBV-infected autoreactive B cells in the CNS.4 Increased serum/plasma interleukin-6 levels in BD7, 17, 18 provide further evidence for a role of the immune system in the pathogenesis of BD.[/quote]

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