Reply to T1D and ADHD/ASD

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[quote=Anonymous]It’s been known for a while that viruses trigger T1D — I believe the thinking is that the mechanism is a combination of (1) genetic predisposition, (2) “molecular mimicry” — where a particular virus/antigen shares structural similarity to pancreatic beta cells, so the individual’s T-cells become “cross-reactive,” ie read the beta cells as viruses and therefore attack, (3) a more generalized inflammatory immune response.

Certain viruses have been identified as being common triggers — human enteroviruses and coxsackie are two big ones, but also some herpes and rotoviruses, mumps, probably covid too, and a handful of others. I believe the individual must have the predisposition, and even then the mechanisms are complex (the immune system is unbelievably complicated and individualized).

In our case, our whole family had a short, dramatic enterovirus about 5-6 months before DC’s diagnosis at 12. Diagnosed ADHD since forever. But my gut is that the virus only accelerated a process that was already underway. Hard to know for sure. [/quote]

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