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[quote=Anonymous][quote=Anonymous]Embryo grading is borderline useless and it has very poor predictive validity regarding whether embryos are genetically normal. Which genetic testing company did the clinic send the biopsies to? I would recommend that you request that the clinic keep your embryos regardless of what the test results are. The accuracy of the genetic results are not 100% and you don’t want to give up any potential changes until you have kid(s) and are done with IVF.  Also make sure to ask if any of the embryos test as genetic abnormal have mosaic aneuploidy. https://www.sciencedirect.com/science/article/pii/S1471491420303130#:~:text=PGT%2DA%20was%20never%20clinically,birth%20chances%20for%20many%20patients.[/quote]

Here’s an image that explains why PGT results can sometimes be inaccurate. The lab is sampling some cells from the trophectoderm (the outside of the embryo that becomes the placenta), but they do not sample inner cell mass that will become the baby. If the cells the samples cells in the trophectoderm have genetic issues, but the inner cell mass is genetically normal, you might reject a potentially viable embryo. This is more likely to occur when embryos have mosaicism (some of the cells are genetically normal and some are not). 
https://ars.els-cdn.com/content/image/1-s2.0-S1471491420303130-b1_lrg.jpg[/quote]

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