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[quote=Anonymous]My husband has non-obstructive azoospermia. When we were trying to conceive 15-16 years ago, he was put on a drug that reduces estrogen production. It was an off-label use of a drug for breast cancer patients. The idea was to increase his testosterone-to-estrogen ratio. Months later, he was tested again, and although he did have some sperm in his sample at that point, his count always remained fewer than 1 million. Genetic testing did not reveal a cause. The urologist felt that there was most likely a micro deletion on husband’s Y chromosome that was too minute for testing to pick up.

We tried IVF w/ ICSI for a couple cycles without success. On our third cycle, dh provided a fresh sample and also underwent TESE. Both sperm samples were used. We ended up with fraternal twins, and our RE thought that one of our children was from the fresh sample and one from TESE, but there’s no way to know which is which. Both children are healthy 14 year olds. I’m sure treatment has improved in the last 15 years.

This is a tough road to travel. Big hugs and best wishes for a successful outcome.[/quote]

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