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[quote=Anonymous]Does anyone know of a fertility clinic in the Nova area that will consider transferring an embryo that tested abnormal for Turner's Syndrome?  Some backstory - I've had 5 IVF cycles and no normal embryos.  My first cycle was at age 38 (I'm now almost 41) and I only had one blast to test, which was a 5AA but came back as Turner's Syndrome.  I was skeptical of the PGT-A result because my DD screened positive for Turner's Syndrome when I was pregnant (it was the DNA test that screened for chromosome issues based on my blood sample) but a subsequent amnio showed she did not have Turner's Syndrome and that it was likely the placental DNA had the abnormal cells, which doesn't affect the baby.  After getting booted out of shared risk because of 2 more failed cycles, I instructed SGF to destroy that frozen embryo (as that was a requirement in order to get our shared risk money back), but 4 cycles later and nothing to show for it, I've often wondered whether that was a false positive or if the same situation where only the placental DNA is affected (which is what is tested with PGT-A, not the fetal DNA).  I'm currently doing a donor egg cycle with SGF and the first FET didn't work.  At my follow-up consult I found out that SGF didn't end up destroying the abnormal embryo from 2 years ago, which now makes me wonder if SGF's mistake is a sign that I should give my only OE embryo a shot.  I've done tons of research regarding PGT-A testing over the past 2 years and have found that the false positive rate is fairly high (typically thought to be between 10-40% false positives).  I also did lots of research on Turner's Syndrome after my first scare with DD and only 1% of Turner's Syndrome embryos result in a live birth (the other 99% are typically chemical pregnancies - if it implant's there's no higher risk of miscarriage).  The 1% that do survive lead a pretty normal life with hormone treatment.  That makes me less concerned about the worst-case outcome of having a child born with Turner's Syndrome.  For anyone unfamiliar with Turner's Syndrome - the actress Linda Hunt and gymnast Missy Marlowe have Turner's Syndrome.

I'd welcome comments but please reserve any judgment - I've had the unique experience of finding out firsthand that testing placental DNA for Turner's Syndrome isn't 100% accurate so keep in mind that my perspective may be different.  Sorry for the long post![/quote]

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