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Infertility Support and Discussion
Reply to "IVF - Dr. Frankfurter at GWU or Dr. Udoff at GIVF "
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[quote=Anonymous]OP here. Thank you all for great inputs. My husband did a test for MFI i.e. DNA sperm fragmentation and it came negative i.e. no MFI. We read up some research papers; when you do ICSI, it helps overcome some male factors as the best of the sperm sample is chosen to do ICSI. That explains why some doctors do not recommend advanced MFI tests if you are doing ICSI. Some other doctors recommend doing sperm DNA fragmentation test just to put your doubts to rest. We found plenty of research papers fidings that DNA sperm fragmentation was predictive of IUI/ICSI effectiveness; and found plenty of research papers that suggested otherwise as well! We found the diagnostic industry flourishes on such divided opinions and clinics advertise an alphabet soup of DNA tests - SCSA, OSI claiming they are a better test of MFI. To cut a long story short, please consider MFI as a factor and test it out at a place your doctor recommends. There are plenty of doctors who believe in MFI. That said, it does not seem to be the smoking gun in our case. [/quote]
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