Reply to Does PGS do anything for me? Or just PGD?

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[quote=Anonymous]I'm the PP poster above.  I'll give you a specific genetic example.  My husband actually has cystic fibrosis.  That means he carries two defective genes that code for a certain protein.  People will only have CF if both copies of that gene are mutated.  We had to do IVF for CF male infertility, but our first step was for me to get a genetic test.  Our child will always inherit one mutated gene from my husband.  As long as I'm not a carrier for CF (which, luckily I'm not), our children practically have zero risk of having CF.  So no PGD was needed for us.  If I were a gene carrier, then our children would have a 50% chance of inheriting my defective CF gene and would have the disease.  So PGD would be used to make a tailor-made test to see if our embryos either inherited the healthy gene, or if they got the defective gene (thus having CF).

So in the example of what would've happened if I had been a carrier, we would probably end up with about ~50% of our embryos not having CF after PGD.  Now, we would need to decide whether or not to do PGS to make sure we didn't have an extra or missing chromosome from those embryos.  This would be an additional test and cost.  [/quote]

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