Reply to Does men has high risk age in terms of pregnancy?

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[quote=Anonymous][quote=Anonymous]He should try to get them in before 40:
https://www.bmj.com/content/363/bmj.k4372
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4854094/pdf/AJA-18-420.pdf
https://www.ncbi.nlm.nih.gov/pubmed/16953005
https://www.ncbi.nlm.nih.gov/pubmed/24577047
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5299396/pdf/tp2016294a.pdf

There is, for example, a six times higher rate of autism in children of men over 40 vs. under 30. For the person saying correlation does not equal causation, the relationship increases monotonically, i.e. the older the man the higher the risk. So it is pretty clearly causative in this case.
[/quote]

It makes sense that offspring of older fathers would be less healthy because older fathers pass on more genetic mutations.  The number of mutations increases with each year of paternal age.  And mutations are usually harmful.

"the diversity in mutation rate of single-nucleotide polymorphism (SNP) is dominated by the age of the father at conception of the child. The effect is an increase of about 2 mutations per year. "
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3548427/

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