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[quote=Anonymous]We had severe MF and I considered PICSI instead of just ICSI.  All docs I talked to (4-5 total, including urologists) said PICSI wasn't helpful.  It's been a while since I did the research so I don't have cites for you, but studies didn't seem to strongly support it's benefit either.  With ICSI the normal looking sperm are selected.  We found additional peace of mind/info by doing a DNA fragmentation test (DH did his testing up at Cornell - there are apparently different test for DNA frag, and Cornell had a preference over the one that Dr. Shin at SG uses), which was the only thing about DH's testing that was normal.  We had fertilization rates on the low end of normal for rounds where my egg quality was bad.  The protocol that gave the best # of blasts also had the best fertilization rate, which was on the high side of normal.  We did DE and the fertilization rate for that round was very high.

Other than PICSI not being particularly helpful, I don't know of down sides to it. [/quote]

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