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Infertility Support and Discussion
Reply to "Anyone able to conquer a dominant follicle problem?"
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[quote=Anonymous][quote=Anonymous]Hi OP, what were your daily stim doses? I suspect that the issue of dominants may have more to do with dose level than with protocol. I had dominants ruin my first two attempts at IVF. I was on antagon and microdose flare protocols at SG when it happened. My RE started dosing me at 250-300 and never dosed me at higher than 450 stims. Subsequently I went to another center that put me on higher dose stims (600/d) and I never saw another dominant. Based on my personal experience, I have my own crazy theory that there are greedy dominant follies that want to hoard all of the available FSH, but if you have an excess FSH available at the very start of a cycle, this can be prevented. I also suspect it may be a waste of time if you start with a low dose and ramp up the dose during the cycle (the way my RE at SG did) because the dominant follicle has already started to take it's lead in the first couple of days, and once it does there's no going back. Like I say, this is just my personal theory on why dominants may happen and how to prevent them. I never had another dominant follie appear in any of the high dose cycles (there were quite a few...and yes, I did finally have success). I'm curious to get your thoughts![/quote] new poster here. I'm pretty young (34 at the time of IVF) and had normal FSH but was a poor responder and had dominant follicle issues (which is usually a sign of poor ovarian reserve/poor response, right?--i was never quite clear on this). In any case, I get WAY over suppressed on the long lupron protocol. What ended up working was a Lupron stop protocol and then very quickly ramping up to super high doses of stims (I was on 450 of gonal f plus 150 of menopur so 600 total). I think I was on 600 by day 3 of stims (started at 450). I still ended up with a dominant follicle that was over mature at the time of retrieval but we also got 4 other eggs. I had one blast left by day 6 and now have a one year old. This was at Shady Grove. [/quote]
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