Reply to Has anyone gotten immunology testing and NOT had anything wrong?

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[quote=Anonymous]OP - you've probably seen some of my other threads.  I have 2 children from FET - I had 1 chemical pregnancy with an untested blast before conceiving my first.  I had 1 chemical pregnancy with a PGS tested blast before conceiving my second.  Then, in my attempts for #3, I had 2 chemical pregnancies and a BFN with my PGS blasts.  Now granted those last 3 chemical pregnancies and BFN with tested blasts were blasts that were frozen, thawed, PGS tested, re-frozen, and re-thawed.  So that may have had something to do with it.  I also had Asherman's/uterine scarring that was fixed by hysteroscopy, so my uterus itself isn't perfect.

At that point, i was exasperated and went to an immune doc.  Like you, EVERYTHING was normal except high TNF alpha.  Mine was around 37.  He recommended prednisone, and either intralipids or IVIG.  We ended up doing low dose prednisone and IVIG with the first of our newly retrieved, newly tested, and once-frozen blast.  and I am now 9 weeks pregnant.

I am VERY VERY skeptical I needed the IVIG.  My hunch is that it was just finally a good quality blast that had been through less trauma.  But I also don't care why it worked.  I was willing to do the kitchen sink approach because I was so exasperated.

I do genuinely believe that if you go testing all these people, you're likely to find something.  I had 2 kids without any immune therapies.  Would I have gotten pregnant this time without that?  Probably eventually.  It may be a total coincidence.  It's hard to separate all the factors (like I said, my hunch is that the factor was that I got a super high quality PGS normal blast that was only frozen once and survived the thaw with 100% cell survival, unlike the last few that had "freezer burn").

IVIG wasn't so bad- it's expensive, and time consuming, but I wanted to feel like I was doing all I could.  I couldn't have handled another chemical pregnancy wondering if I should have done the IVIG.

Now that I graduated my RE and am with my OB, I told him about it and he thinks all the immune stuff is B.S.  I think even my RE kinda thought it was B.S. to tell the truth.

How far along was your miscarriage?  [/quote]

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