More evidence for folate malabsorption in Neurodivergent bodies

[Anonymous]

Anonymous wrote:How is folinic acid different from L-methyfolate? I thought the very most basic form was the latter?

Theyre both active forms of folate, yes. But folinic acid is the precursor. It can be converted to other forms like l methylfolate, but l methylfolate cant be converted to folinic acid. Folinic acid is used in more processes like dna repair. It also has fewer possible side effects.

[Anonymous]

Anonymous wrote:I stumbled upon this thread and am wondering if someone can point me in a direction.

DS is 30 and was diagnosed as PANDAS at NIH at age 11 but didn't qualify for the study. He had his first of many episodes (strep induced) at age 6 and the last known strep caused outbreak was in his 20s. His debilitating OCD has made him unable to finish school or to work. He did exposure and response prevention therapy for a couple of years with prophylactic antibiotics, which carried him through high school, but in college he fell apart after a couple of strep episodes. He has refused further ERP treatment and any other therapy, which in any case has proven counterproductive as his (distorted) views of the psychologists just become part of his obsessive ruminations.

The FRAT test looks well worth looking into and something he might agree to do. Where could I find a doctor who might agree to do this testing for adult?

Honestly, we have just about given up. I have resigned myself to saving enough money to support him for life and my daughter has resigned herself to having responsibility for him once DH and I are gone.

Thanks for any help.

We really like dr. Dan Rossignol and travel to FL to see him. He brought all of the folate receptor deficiency and FRAT test info up before I started seeing anything about it online. We just go in person once a year and then have virtual visits as needed. I had posted about him before and a parent just went off about how he was a con, took their money, etc. We've honestly paid less to see him and get the whole panel of bloodwork done annually there, and he runs it through insurance (the bloodwork portion). He had my daughter do a longer eeg b/c he was convinced my dd was having seizures even though the dr at georgetown didn't think so. We ended up doing the 24 hour eeg at Georgetown b/c it was easier to do it locally, and the Georgetown neuro was shocked to find out she was having seizures that just didn't show up on the one hour eegs. There have been enough little things that Dr. Rossignol has been correct on that we will continue to go see him annually. If you can't find anyone locally, I think it would be worth a visit.

[Anonymous]

What doctors in the DC area are aware of this and would prescribe the FRAT test?

[Anonymous]

Make your doctors aware. It's mind boggling that a doctor would agree to treat a person with asd or pans etc and not be aware of current research. And some of this research goes back to 2012.

[Anonymous]

Well, well, well, well, well.
Looks like it is the folate per the HHS report.
Kudos to everyone who took it seriously

[Anonymous]

Anonymous wrote:Well, well, well, well, well.
Looks like it is the folate per the HHS report.
Kudos to everyone who took it seriously

Care to share your insight?

[Anonymous]

U.S. Health Secretary Robert F. Kennedy Jr. plans to announce that use of Kenvue's (KVUE.N) popular over-the-counter pain medication Tylenol in pregnant women is potentially linked to autism, contrary to medical guidelines that say it is safe to use, the Wall Street Journal reported on Friday, citing people familiar with the matter.

Kennedy, in the report, will also suggest a medicine derived from folate called folinic acid can be used to treat symptoms of autism in some people, the WSJ reported.

Kennedy to link Tylenol use in pregnancy to autism, report says - https://www.reuters.com/business/healthcare-pharmaceuticals/kennedy-link-tylenol-use-pregnancy-autism-report-says-2025-09-05/

[Anonymous]

Anonymous wrote:This is very interesting and now the thought has to be with pregnancy supplements possibly being the cause.

Because most autistic and neurodivergent kids seem to come from middle and upper middle class getting proper supplements and care. Although I still think age of mother plays a very important part that society doesn’t want to admit.

It is known that older parents, especially older fathers is linked to autism

[Anonymous]

Anonymous wrote:Well, well, well, well, well.
Looks like it is the folate per the HHS report.
Kudos to everyone who took it seriously

Kudos to everyone who isn't fool enough to believe RFK Jr. Maybe it's folate maybe it's not, but this is nothing new.

[Anonymous]

Anonymous wrote:Well, well, well, well, well.
Looks like it is the folate per the HHS report.
Kudos to everyone who took it seriously

Uh, there's nothing really new here.

[Anonymous]

Anonymous wrote:

Anonymous wrote:Well, well, well, well, well.
Looks like it is the folate per the HHS report.
Kudos to everyone who took it seriously

Kudos to everyone who isn't fool enough to believe RFK Jr. Maybe it's folate maybe it's not, but this is nothing new.

Hey maybe this can be one good thing out of many terrible things he does (make it easier to get leucovorin treatment for kids with autism)

[Anonymous]

Anonymous wrote:

Anonymous wrote:Well, well, well, well, well.
Looks like it is the folate per the HHS report.
Kudos to everyone who took it seriously

Uh, there's nothing really new here.

Actually the head of HHS coming out to say that autism is largely folate related and leucovorin is therapeutic should do an awful lot to get testing and the drug covered by insurance where it isnt. And many physicians are refusing to Rx leucovorin. There will be alot more pressure on them to stop gatekeeping.

[Anonymous]

Anonymous wrote:

Anonymous wrote:Well, well, well, well, well.
Looks like it is the folate per the HHS report.
Kudos to everyone who took it seriously

Care to share your insight?

Kennedy is to report that leucovorin (a form of folinic acid) is therapeutic in autism. He is also pointing the finger at acetaminophen as a folate reducer in pregnancy. This will lead to examination of what else may reduce fetslnfolate including the most likely cause: folic acid in prenatal vitamins and enriched food.

[Anonymous]

Anonymous wrote:

Anonymous wrote:Well, well, well, well, well.
Looks like it is the folate per the HHS report.
Kudos to everyone who took it seriously

Kudos to everyone who isn't fool enough to believe RFK Jr. Maybe it's folate maybe it's not, but this is nothing new.

Yes, there's been a correlation in a couple observational studies but anyone who has done any research knows that correlations in observation studies often turn out to be data blips and aren't replicable or pan out in further study. These observational studies already have contradictory data.

Studying it, sure. Announcing it as a cause? Completely unsupported by existing data.

[Anonymous]

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:Well, well, well, well, well.
Looks like it is the folate per the HHS report.
Kudos to everyone who took it seriously

Uh, there's nothing really new here.

Actually the head of HHS coming out to say that autism is largely folate related and leucovorin is therapeutic should do an awful lot to get testing and the drug covered by insurance where it isnt. And many physicians are refusing to Rx leucovorin. There will be alot more pressure on them to stop gatekeeping.

Or maybe it will cause the idea of folate to lose credibility. Wonder why ...