FDA removed black box warning for HRT

[Anonymous]

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:I don’t trust anything RFK jr or trump says. This FDA is currently SUS so I’m seeing this as a red flag. If they promote it, I should not consider it.
If it was legitimately safe, Melania should have made the announcement. Woman to women.
I’ll wait until we have actual medical experts back in the FDA before I trust their advice.

Wow - you would have given it more credence out of Melania’s mouth? That’s moronic.

HRT has enabled me to sleep through the night regularly for the first time in a year. Game changer.

And has increased your risk of stroke and cancer.

Well, my thyroid stopped working in my 20s and I need thyroid replacement hormone for the rest of my life to function because my body doesn’t make thyroid hormone anymore. Does that raise my risk of stroke and cancer? I don’t know, maybe. But I’d rather die than live half dead. I don’t see how it’s different with progesterone and estrogen.

[Anonymous]

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:I don’t trust anything RFK jr or trump says. This FDA is currently SUS so I’m seeing this as a red flag. If they promote it, I should not consider it.
If it was legitimately safe, Melania should have made the announcement. Woman to women.
I’ll wait until we have actual medical experts back in the FDA before I trust their advice.

Wow - you would have given it more credence out of Melania’s mouth? That’s moronic.

HRT has enabled me to sleep through the night regularly for the first time in a year. Game changer.

And has increased your risk of stroke and cancer.

Well, my thyroid stopped working in my 20s and I need thyroid replacement hormone for the rest of my life to function because my body doesn’t make thyroid hormone anymore. Does that raise my risk of stroke and cancer? I don’t know, maybe. But I’d rather die than live half dead. I don’t see how it’s different with progesterone and estrogen.

You don’t see how thyroid hormones and estrogen/progesterone are different? Ok.

[Anonymous]

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:I don’t trust anything RFK jr or trump says. This FDA is currently SUS so I’m seeing this as a red flag. If they promote it, I should not consider it.
If it was legitimately safe, Melania should have made the announcement. Woman to women.
I’ll wait until we have actual medical experts back in the FDA before I trust their advice.

Wow - you would have given it more credence out of Melania’s mouth? That’s moronic.

HRT has enabled me to sleep through the night regularly for the first time in a year. Game changer.

And has increased your risk of stroke and cancer.

Well, my thyroid stopped working in my 20s and I need thyroid replacement hormone for the rest of my life to function because my body doesn’t make thyroid hormone anymore. Does that raise my risk of stroke and cancer? I don’t know, maybe. But I’d rather die than live half dead. I don’t see how it’s different with progesterone and estrogen.

You don’t see how thyroid hormones and estrogen/progesterone are different? Ok.

What kind of zingers do you have about cortisol vs prolactin? You could get an entire endocrinology stand-up routine going

[Anonymous]

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:I don’t trust anything RFK jr or trump says. This FDA is currently SUS so I’m seeing this as a red flag. If they promote it, I should not consider it.
If it was legitimately safe, Melania should have made the announcement. Woman to women.
I’ll wait until we have actual medical experts back in the FDA before I trust their advice.

+1

I don't get medical advice from TikTok or people with brain worms who have clearly parted with reality.

You won’t discuss this with your gynecologist? You’ll just wait around for the FDA at some point years in the future to maybe- just maybe- say something else?

Your eyesight is failing you in your old age. Here is what I said:
“ I don't get medical advice from TikTok or people with brain worms who have clearly parted with reality. “

[Anonymous]

Let’s get some education backed discussion going.

The original capital HRT was… conjugated equine estrogens (CEE), often sold under the brand name Premarin®.
For women who still had their uterus, a progestin was added to the estrogen to prevent endometrial cancer. The standard combination was CEE plus medroxyprogesterone acetate (MPA), the active ingredient in Provera®, which was often prescribed together as the combined pill Prempro.

It was a high dose, pill form, in women around 60.

Now being offered … 17β-estradiol, which has the same chemical structure as the primary estrogen produced by the human ovaries (making it "bioidentical"), rather than animal-derived or synthetic estrogens. This is available in various forms, including pills (e.g., Estrace, Gynodiol), patches (e.g., Vivelle-Dot, Minivelle), gels, and sprays.

What we really need is more money towards women research .. research that was cancelled last Spring.

[Anonymous]

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:I don’t trust anything RFK jr or trump says. This FDA is currently SUS so I’m seeing this as a red flag. If they promote it, I should not consider it.
If it was legitimately safe, Melania should have made the announcement. Woman to women.
I’ll wait until we have actual medical experts back in the FDA before I trust their advice.

+1

I don't get medical advice from TikTok or people with brain worms who have clearly parted with reality.

You won’t discuss this with your gynecologist? You’ll just wait around for the FDA at some point years in the future to maybe- just maybe- say something else?

Your eyesight is failing you in your old age. Here is what I said:
“ I don't get medical advice from TikTok or people with brain worms who have clearly parted with reality. “

No one is talking about getting medical advice from those sources here.

[Anonymous]

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:I don’t trust anything RFK jr or trump says. This FDA is currently SUS so I’m seeing this as a red flag. If they promote it, I should not consider it.
If it was legitimately safe, Melania should have made the announcement. Woman to women.
I’ll wait until we have actual medical experts back in the FDA before I trust their advice.

Wow - you would have given it more credence out of Melania’s mouth? That’s moronic.

HRT has enabled me to sleep through the night regularly for the first time in a year. Game changer.

And has increased your risk of stroke and cancer.

Well, my thyroid stopped working in my 20s and I need thyroid replacement hormone for the rest of my life to function because my body doesn’t make thyroid hormone anymore. Does that raise my risk of stroke and cancer? I don’t know, maybe. But I’d rather die than live half dead. I don’t see how it’s different with progesterone and estrogen.

You don’t see how thyroid hormones and estrogen/progesterone are different? Ok.

Why are estrogen/progesterone sacrosanct? One hormone is okay but not the other?

I had intense throwing up level menstrual cramps as a teen. BC was the miracle solution. Yet, those cramps were natural. Should I have just suffered?

[Anonymous]

HRT (estradiol patches and oral progesterone) has been transformative for me. I have yet to see evidence of it causing strokes. When you put that on the internet, you are spreading more misinformation and it's not helpful. I wish another, much more credible administration had made this decision but I also don't disagree with it.


Congrats to all those who have shared that they have gotten through perimenopause/menopause with few problems. Sounds lovely but your experience is pretty irrelevant to anyone else's experience. Also, there is no prize for avoiding night sweats/mood swings/frozen shoulder/joint pain (etc) and acting smug about it.

[Anonymous]

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:I don’t trust anything RFK jr or trump says. This FDA is currently SUS so I’m seeing this as a red flag. If they promote it, I should not consider it.
If it was legitimately safe, Melania should have made the announcement. Woman to women.
I’ll wait until we have actual medical experts back in the FDA before I trust their advice.

Wow - you would have given it more credence out of Melania’s mouth? That’s moronic.

HRT has enabled me to sleep through the night regularly for the first time in a year. Game changer.

And has increased your risk of stroke and cancer.

Not stroke, bc presumably she’s not taking oral estrogen. Maybe a tiny absolute increase in breast cancer risk, which depending on family history is likely outweighed by a decrease in risk of heart disease, diabetes, and all-cause mortality.

[Anonymous]

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:I don’t trust anything RFK jr or trump says. This FDA is currently SUS so I’m seeing this as a red flag. If they promote it, I should not consider it.
If it was legitimately safe, Melania should have made the announcement. Woman to women.
I’ll wait until we have actual medical experts back in the FDA before I trust their advice.

+1

I don't get medical advice from TikTok or people with brain worms who have clearly parted with reality.

You won’t discuss this with your gynecologist? You’ll just wait around for the FDA at some point years in the future to maybe- just maybe- say something else?

Your eyesight is failing you in your old age. Here is what I said:
“ I don't get medical advice from TikTok or people with brain worms who have clearly parted with reality. “

No one is talking about getting medical advice from those sources here.

Here you go:
https://locations.myeyedr.com/

You're welcome!

[Anonymous]

Anonymous wrote:HRT (estradiol patches and oral progesterone) has been transformative for me. I have yet to see evidence of it causing strokes. When you put that on the internet, you are spreading more misinformation and it's not helpful. I wish another, much more credible administration had made this decision but I also don't disagree with it.


Congrats to all those who have shared that they have gotten through perimenopause/menopause with few problems. Sounds lovely but your experience is pretty irrelevant to anyone else's experience. Also, there is no prize for avoiding night sweats/mood swings/frozen shoulder/joint pain (etc) and acting smug about it.

FYI if it passed through the liver it would potentially increase risk of clots. This is why no one gives oral estrogen — only patches and gels. Oral progesterone doesn’t have that effect, which is why you can take it in pill form.

Agree with your latter point, though for some posters, the smug feeling IS the prize. Kind of a hollow prize if you ask me, but I guess it must meet some inner need. We are all muddling through an uncertain world as best we can, I suppose.

[Anonymous]

Anonymous wrote:Let’s get some education backed discussion going.

The original capital HRT was… conjugated equine estrogens (CEE), often sold under the brand name Premarin®.
For women who still had their uterus, a progestin was added to the estrogen to prevent endometrial cancer. The standard combination was CEE plus medroxyprogesterone acetate (MPA), the active ingredient in Provera®, which was often prescribed together as the combined pill Prempro.

It was a high dose, pill form, in women around 60.

Now being offered … 17β-estradiol, which has the same chemical structure as the primary estrogen produced by the human ovaries (making it "bioidentical"), rather than animal-derived or synthetic estrogens. This is available in various forms, including pills (e.g., Estrace, Gynodiol), patches (e.g., Vivelle-Dot, Minivelle), gels, and sprays.

What we really need is more money towards women research .. research that was cancelled last Spring.

So basically there is no consistency in the type of hormone or the method of administration, and we are someone meant to infer … what? I cannot infer anything one way or another other than that it is reason to infer that the greatest risks are starting at 60+.

Yes we need better research.

[Anonymous]

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:I don’t trust anything RFK jr or trump says. This FDA is currently SUS so I’m seeing this as a red flag. If they promote it, I should not consider it.
If it was legitimately safe, Melania should have made the announcement. Woman to women.
I’ll wait until we have actual medical experts back in the FDA before I trust their advice.

Wow - you would have given it more credence out of Melania’s mouth? That’s moronic.

HRT has enabled me to sleep through the night regularly for the first time in a year. Game changer.

And has increased your risk of stroke and cancer.

Well, my thyroid stopped working in my 20s and I need thyroid replacement hormone for the rest of my life to function because my body doesn’t make thyroid hormone anymore. Does that raise my risk of stroke and cancer? I don’t know, maybe. But I’d rather die than live half dead. I don’t see how it’s different with progesterone and estrogen.

You don’t see how thyroid hormones and estrogen/progesterone are different? Ok.

Why are estrogen/progesterone sacrosanct? One hormone is okay but not the other?

I had intense throwing up level menstrual cramps as a teen. BC was the miracle solution. Yet, those cramps were natural. Should I have just suffered?

Ffs. Nobody said any hormone is “sacrosanct.” The point is that your thyroid failing in your 20s is totally different from menopause in your 50s. To compare the two is nonsensical.

[Anonymous]

Anonymous wrote:HRT (estradiol patches and oral progesterone) has been transformative for me. I have yet to see evidence of it causing strokes. When you put that on the internet, you are spreading more misinformation and it's not helpful. I wish another, much more credible administration had made this decision but I also don't disagree with it.


Congrats to all those who have shared that they have gotten through perimenopause/menopause with few problems. Sounds lovely but your experience is pretty irrelevant to anyone else's experience. Also, there is no prize for avoiding night sweats/mood swings/frozen shoulder/joint pain (etc) and acting smug about it.

If you don’t know about the stroke risk your doctor didn’t educate you well.

https://www.ahajournals.org/doi/10.1161/STROKEAHA.121.038659

[Anonymous]

Anonymous wrote:

Anonymous wrote:HRT (estradiol patches and oral progesterone) has been transformative for me. I have yet to see evidence of it causing strokes. When you put that on the internet, you are spreading more misinformation and it's not helpful. I wish another, much more credible administration had made this decision but I also don't disagree with it.


Congrats to all those who have shared that they have gotten through perimenopause/menopause with few problems. Sounds lovely but your experience is pretty irrelevant to anyone else's experience. Also, there is no prize for avoiding night sweats/mood swings/frozen shoulder/joint pain (etc) and acting smug about it.

If you don’t know about the stroke risk your doctor didn’t educate you well.

https://www.ahajournals.org/doi/10.1161/STROKEAHA.121.038659

What a tiny difference. I feel better about my risks after reading that.