So many friends on GLPs

[Anonymous]

Dangerous poster makes sense. If you’re just overweight and not obese you should make every effort to shed the weight the old fashioned way. Not sure what’s controversial about that. If that doesn’t work then yeah take the injections.

[Anonymous]

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:I just saw my 52 year old sister; she is positively gaunt and I’d guess about 110 lbs (5’5”). She entered menopause complaining of weight gain (and made mention shedding gained about 50 pounds). We think her “menopause doctor” prescribed GLP and in 4 months, had a dramatic weight loss.

History of yoyo dieting and weight gain/loss and an ED.

She looks awful but thinks she looks fabulous.

I wonder how these bodies will fight an illness such as a cancer.

Since obesity is strongly connected to increased cancer risk and advancement and worse outcomes, the answer is way better than it would have otherwise.

https://www.cancer.gov/about-cancer/causes-prevention/risk/obesity/obesity-fact-sheet

Oh, and you are an ignorant imbecile.

Just because you are shedding fat from injectables doesn’t mean you are making your body healthier. You might be losing fat but you need to exercise in an intentional and consistent manner to make sure your organs (ie the heart) and muscles are stronger.

[Anonymous]

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:I just saw my 52 year old sister; she is positively gaunt and I’d guess about 110 lbs (5’5”). She entered menopause complaining of weight gain (and made mention shedding gained about 50 pounds). We think her “menopause doctor” prescribed GLP and in 4 months, had a dramatic weight loss.

History of yoyo dieting and weight gain/loss and an ED.

She looks awful but thinks she looks fabulous.

I wonder how these bodies will fight an illness such as a cancer.

Since obesity is strongly connected to increased cancer risk and advancement and worse outcomes, the answer is way better than it would have otherwise.

https://www.cancer.gov/about-cancer/causes-prevention/risk/obesity/obesity-fact-sheet

Oh, and you are an ignorant imbecile.

Pp has a point. How a malnourished body will fight an illness. However, The fact that you need to insult everyone that doesn’t validate you tells me that you are worried about your decision.

[Anonymous]

Anonymous wrote:I just don't understand why you people feel the need to judge and hate. Just stop thinking about it, move on, live your own life, and shut up about mine. I've got it under control, thanks.

Stop caring what other people think about you.

[Anonymous]

Anonymous wrote:

Anonymous wrote:I’ve heard horror stories about it causing major digestive issues—either severe constipation or the opposite—and that gives me pause every time I think about trying it. I’ve been fighting to loose an extra 15 pounds of menopause weight for while now.

I started with microdosing since I had a similar amount to lose. So injection is .15 as opposed to the lowest prescription dose of .25. It works without a lot of the digestive upset. Maybe a little at first but I’ve adjusted.

I also don’t lose weight quite as quickly but am down 12 pounds in about as many weeks. I will add it has almost eliminated my peri symptoms including night sweats which has been a bonus. But hair loss is real. Not overwhelming but definitely happening.

I noticed a couple posters mention hair loss. Is that a side effect of the GLP drug, or is that something that happens anyway with rapid weight loss due to cutting calories?

And if it is a drug side effect, does it happen with all of the GLP drugs or just some of them? Does a smaller dose prevent it?

[Anonymous]

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:I just saw my 52 year old sister; she is positively gaunt and I’d guess about 110 lbs (5’5”). She entered menopause complaining of weight gain (and made mention shedding gained about 50 pounds). We think her “menopause doctor” prescribed GLP and in 4 months, had a dramatic weight loss.

History of yoyo dieting and weight gain/loss and an ED.

She looks awful but thinks she looks fabulous.

I wonder how these bodies will fight an illness such as a cancer.

Since obesity is strongly connected to increased cancer risk and advancement and worse outcomes, the answer is way better than it would have otherwise.

https://www.cancer.gov/about-cancer/causes-prevention/risk/obesity/obesity-fact-sheet

Oh, and you are an ignorant imbecile.

Pp has a point. How a malnourished body will fight an illness. However, The fact that you need to insult everyone that doesn’t validate you tells me that you are worried about your decision.

Did you see the research listed? MUCH BETTER CHANCE WITH CANCER WHEN NOT OBESE. It's right there. You could have read it. But no, you choose to ignore the actual medicine and go with a dangerous combination of your bias and facts you made up.

That's why you're an imbecile also.

[Anonymous]

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:I just reconnected with a group of college friends and we met up for dinner. Every single one looks fantastic - maybe even better in their mid 40s than their 20s. I came to find out that 3 of the 4 women are on GLPs which helped them lose 10-20 lbs (none were overweight) and now they are just micro dosing to maintain. They all said they feel better then they have in years, didn’t have bad side effects, and focus on eating protein so they don’t lose muscle.

Anyway, here I am struggling to lose 10-15 lbs like always - restricting my calories, working out a ton, etc, and barely seeing the scale move. Every time I do lose it it ends up coming back again.

Just wondering why I don’t take the easier route like so many others. I would need to find a doctor to prescribe it since my PCP won’t (despite telling me my BMI is too high and I need to focus on losing 10-15 lbs).

This is why no one talks to you about it. You are a judgey friend. No one needs that in their life.

Not OP but it’s true. It is the easier route. Exercising hard annd regularly at the same time as restricting calories when you work full time and are raising kids is hard. Injecting yourself with weight-loss drugs that work = easy.

Ok I'm going to blow your mind here. I've been getting up at 5am to exercise 5 days/week (3 days lifting, 2 days cardio) and walking at least 8k+ steps per day for 3 years. I've dutifully tracked macros nearly every single day. I meal prepped breakfast and lunch and thoughtfully planned dinners. I lost 12 pounds and then got stuck for 2 years+.

I'm on Zepbound now and I still do all of those things. But now, I've dropped 14 pounds in 2.5 months-- on a "starter"-- not even therapeutic dose. I'm sure there are people who use it to suppress their appetite and when they do eat, eat like shit and don't exercise. But my point is for those of us trying to make lasting changes that support health its STILL hard, albeit admittedly not as frustrating as it used to be.

Your story is making me question how healthy all of this is. If your body is fighting you this hard to keep pounds that you have to drug yourself to lose weight, how healthy is this drug? Maybe you shouldn't be losing this weight and the doctors are actually wrong about all of this. Wouldn't be the first time doctors got it wrong.

It’s a fair point and something I reflected on for ~6 months while considering taking them.

I’ve also been thinking about the mechanisms of action. I get that most people just don’t eat when they’re on them, but I’ve been very intentional about getting adequate nutrition. I’m eating on average 300 calories less per day than when I wasn’t on them. By that math I should be losing 1 pound about every 11 days. But I’m losing ~1.5 per week which makes me wonder if there’s some metabolic or biochemical process that’s broken in me that this is somehow repairing. My doctor reflected on this too saying she had many folks (mostly women) who are having similar experiences. Her hypotheses were about chronic dieting causing damage or possibly food supply issues. All of my labs in terms of hormones, insulin resistance, thyroid, etc were good, so there’s no obvious explanation.

The thing that pushed me over the edge to do it was that my labs were starting to deteriorate a bit. My LDL was too high and HDL was too low even with typical lifestyle modifications and they have been creeping in the wrong direction.

Thanks for this response. It makes a lot of sense.

[Anonymous]

Anonymous wrote:

Anonymous wrote:The only way I've successfully lost weight (I'm 55 now) in the last few years is by eating twice a day within an 8 hr window. I gain a few pounds every school year and every summer I get rid of those pounds by time restricted eating (ends up being fewer calories in a day) and eating higher fats and protein. Breakfast is avocado toast or an omelet with a bit of berries and nuts. I'm stuffed after these because they are full of healthy fat. I don't snack because breakfast fills me up. Dinner is done by 6pm and then I don't eat again until 10am. Works every year and fairly quickly too. I'm down 6 pounds in the last three weeks.

That doesn't sound healthy.

What? Eating twice a day? Your body doesn’t need the constant intake a good especially if you’re overweight. You need to give it a chance to burn some fat if you want to lose weight. Eating 3 meals a day plus snacks won’t give it a chance to switch to fat burning mode.

[Anonymous]

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:I just saw my 52 year old sister; she is positively gaunt and I’d guess about 110 lbs (5’5”). She entered menopause complaining of weight gain (and made mention shedding gained about 50 pounds). We think her “menopause doctor” prescribed GLP and in 4 months, had a dramatic weight loss.

History of yoyo dieting and weight gain/loss and an ED.

She looks awful but thinks she looks fabulous.

I wonder how these bodies will fight an illness such as a cancer.

Since obesity is strongly connected to increased cancer risk and advancement and worse outcomes, the answer is way better than it would have otherwise.

https://www.cancer.gov/about-cancer/causes-prevention/risk/obesity/obesity-fact-sheet

Oh, and you are an ignorant imbecile.

Just because you are shedding fat from injectables doesn’t mean you are making your body healthier. You might be losing fat but you need to exercise in an intentional and consistent manner to make sure your organs (ie the heart) and muscles are stronger.

100%

Thigh girth has been linked to longer life. Muscle

VO2 max numbers have also increase lifespan. That’s cardio

Exercise reduces cancer risk (not about fat loss) but increases blood flow to the brain, reduces risk of cancer and heart attacks from the immune factors it stimulates.

You can be skinny and unhealthy. 100%

[Anonymous]

Anonymous wrote:What is your question?

+1

[Anonymous]

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:I just wish we knew how we got here. Maybe these drugs can drastically improve the health of more well to do Americans but they were not needed 50 years ago. What did we do to our food and lifestyle that drug companies get this boon?

I think chemicals in our foods definitely helped get us here. I posted on another thread that going off processed food has been a game changer for me. Food noise went away except for when I am getting hungry for a meal and it's much easier to eat in my weight-loss range. The problem is it is crazy time consuming and hard to sustain when life is busier.

I have friends on GLPs and it has been incredible. They went on when they moved toward obesity at a doctor's recommendation. I am slightly overweight and now finally losing. I have not asked about it because some of the the rarer and more serious side effects are things that run in my family (without the medication) so I just don't want to go there unless I must, but I do think the drugs seem pretty amazing.

It’s for sure processed food. I’m here in the UK right now, and the junk in their supermarkets is as bad or worse than ours. And they are just as fat as the US is. I would honestly say that the volume of sugar is higher here, and candy more pervasive.

I went looking for normal tart cherry juice at two supermarkets - tesco and sainsbury - not a thing. Lots of sugary blended products though.

It’s extremely difficult, time consuming, and expensive to navigate around all the junk in our food system.

try waitrose. one of the larger ones. or a M&S food hall but yess, finding pure food with garbage in it is really really difficult.

[Anonymous]

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:I just saw my 52 year old sister; she is positively gaunt and I’d guess about 110 lbs (5’5”). She entered menopause complaining of weight gain (and made mention shedding gained about 50 pounds). We think her “menopause doctor” prescribed GLP and in 4 months, had a dramatic weight loss.

History of yoyo dieting and weight gain/loss and an ED.

She looks awful but thinks she looks fabulous.

I wonder how these bodies will fight an illness such as a cancer.

Since obesity is strongly connected to increased cancer risk and advancement and worse outcomes, the answer is way better than it would have otherwise.

https://www.cancer.gov/about-cancer/causes-prevention/risk/obesity/obesity-fact-sheet

Oh, and you are an ignorant imbecile.

Just because you are shedding fat from injectables doesn’t mean you are making your body healthier. You might be losing fat but you need to exercise in an intentional and consistent manner to make sure your organs (ie the heart) and muscles are stronger.

100%

Thigh girth has been linked to longer life. Muscle

VO2 max numbers have also increase lifespan. That’s cardio

Exercise reduces cancer risk (not about fat loss) but increases blood flow to the brain, reduces risk of cancer and heart attacks from the immune factors it stimulates.

You can be skinny and unhealthy. 100%

Sorry but

Exercise reduces cancer risk (not about fat loss)

You also did not read the research. Obesity and cancer have a direct correlation, independent of exercise level.

Here's more

https://www.cancer.org/cancer/risk-prevention/diet-physical-activity/body-weight-and-cancer-risk.html
https://www.mdanderson.org/publications/focused-on-health/how-does-obesity-cause-cancer.h27Z1591413.html
https://www.thelancet.com/journals/lanepe/article/PIIS2666-7762(24)00201-1/fulltext

Read before you post. It's dangerous not to.

[Anonymous]

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:I just saw my 52 year old sister; she is positively gaunt and I’d guess about 110 lbs (5’5”). She entered menopause complaining of weight gain (and made mention shedding gained about 50 pounds). We think her “menopause doctor” prescribed GLP and in 4 months, had a dramatic weight loss.

History of yoyo dieting and weight gain/loss and an ED.

She looks awful but thinks she looks fabulous.

I wonder how these bodies will fight an illness such as a cancer.

Since obesity is strongly connected to increased cancer risk and advancement and worse outcomes, the answer is way better than it would have otherwise.

https://www.cancer.gov/about-cancer/causes-prevention/risk/obesity/obesity-fact-sheet

Oh, and you are an ignorant imbecile.

Pp has a point. How a malnourished body will fight an illness. However, The fact that you need to insult everyone that doesn’t validate you tells me that you are worried about your decision.

Did you see the research listed? MUCH BETTER CHANCE WITH CANCER WHEN NOT OBESE. It's right there. You could have read it. But no, you choose to ignore the actual medicine and go with a dangerous combination of your bias and facts you made up.

That's why you're an imbecile also.

I am not sure how you think these two are related. The study is talking about the RISK of getting cancer NOT the chance of surviving cancer which is pp’s point.

[Anonymous]

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:I’ve heard horror stories about it causing major digestive issues—either severe constipation or the opposite—and that gives me pause every time I think about trying it. I’ve been fighting to loose an extra 15 pounds of menopause weight for while now.

I started with microdosing since I had a similar amount to lose. So injection is .15 as opposed to the lowest prescription dose of .25. It works without a lot of the digestive upset. Maybe a little at first but I’ve adjusted.

I also don’t lose weight quite as quickly but am down 12 pounds in about as many weeks. I will add it has almost eliminated my peri symptoms including night sweats which has been a bonus. But hair loss is real. Not overwhelming but definitely happening.

I noticed a couple posters mention hair loss. Is that a side effect of the GLP drug, or is that something that happens anyway with rapid weight loss due to cutting calories?

And if it is a drug side effect, does it happen with all of the GLP drugs or just some of them? Does a smaller dose prevent it?

I didn’t lose weight rapidly. Less than a pound a week. I still lost a lot of hair. So much I had to stop. The hair loss stopped when I hadn’t had a shot in around 3 weeks.

A lot of people on the internet will tell you that it’s NOt the shot, it’s rapid weight loss. But many of us have experienced hair loss, including the day after a shot a good amount of hair coming out.

It shouldn’t prevent you from taking the shot, but pay attention to it. Unfortunately I noticed after I had already lost a good bit of hair.

[Anonymous]

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:I just saw my 52 year old sister; she is positively gaunt and I’d guess about 110 lbs (5’5”). She entered menopause complaining of weight gain (and made mention shedding gained about 50 pounds). We think her “menopause doctor” prescribed GLP and in 4 months, had a dramatic weight loss.

History of yoyo dieting and weight gain/loss and an ED.

She looks awful but thinks she looks fabulous.

I wonder how these bodies will fight an illness such as a cancer.

Since obesity is strongly connected to increased cancer risk and advancement and worse outcomes, the answer is way better than it would have otherwise.

https://www.cancer.gov/about-cancer/causes-prevention/risk/obesity/obesity-fact-sheet

Oh, and you are an ignorant imbecile.

Pp has a point. How a malnourished body will fight an illness. However, The fact that you need to insult everyone that doesn’t validate you tells me that you are worried about your decision.

Did you see the research listed? MUCH BETTER CHANCE WITH CANCER WHEN NOT OBESE. It's right there. You could have read it. But no, you choose to ignore the actual medicine and go with a dangerous combination of your bias and facts you made up.

That's why you're an imbecile also.

PP is talking about malnourished people. If you are not one of them you shouldn’t worry too much.