How long have glp 1s been in use?

[Anonymous]

I need to lose weight for health reasons and I’m struggling to do so on my own. I have a bit of anxiety about taking new medication’s and new drugs. I’m wondering how long GLPs have been used? I realize the weight loss use is newer, but maybe it was being used for many years to treat something else? It would make me feel more comfortable to understand if the dog had been around for a while

[Anonymous]

They were approved for use for diabetes in 2005 and for weight loss in 2014.

[Anonymous]

Anonymous wrote:They were approved for use for diabetes in 2005 and for weight loss in 2014.

I knew about the diabetes but I'm surprised about 2014. How is it they seem to have exploded in the last couple of years?

[Anonymous]

People will go on about how Ozempic, which is a GLP1 and is the same drug as Wegovy (both are semaglutide), has been on the market for over 6 years. And this is true, it has been. However, Wegovy is given at higher doses. So yes, semaglutide has been around, which is reassuring. But it has not been prescribed at these higher doses, or for this particular complaint (obesity), and that is a different thing. Potentially a very different thing.

[Anonymous]

I am worried about long term implications of these drugs. I think the immediate side effects are well understood and manageable, I worry about what we don’t know yet. At the same time, I could use help with losing weight

[Anonymous]

I know someone who I realize, in retrospect, was on one of these in 2019. She said she was focusing on health and getting “vitamin” injections at a weight loss clinic. Now I’m like “oh, yeah, makes sense.”

When a mid-50s woman who has been overweight her whole life starts losing weight at a rapid pace you kinda know it’s not completely without help.

[Anonymous]

Look, you will need to wait longer than your lifetime to prove a recent drug has no lifetime effects. But being overweight has real, known effects.

I was trying to avoid having a heart attack in my 40s. Hypothetical risk from a drug that's been on the market for a while is about as concerning to me as cancer risk from my phone.

[Anonymous]

Anonymous wrote:Look, you will need to wait longer than your lifetime to prove a recent drug has no lifetime effects. But being overweight has real, known effects.

I was trying to avoid having a heart attack in my 40s. Hypothetical risk from a drug that's been on the market for a while is about as concerning to me as cancer risk from my phone.

This. OP, I was hesitant too. Ans I am still shocked by all the people willing to take even a small risk for 10, 20, even 30 pounds to get down to their idea (versus healthy) weight. But if you need to lose wight for health reasons (and I certainly do), you are taking plenty of risks by not losing the eight, too. And there are people who have been on these drugs for 20 years. That should be reassuring.

[Anonymous]

Anonymous wrote:I know someone who I realize, in retrospect, was on one of these in 2019. She said she was focusing on health and getting “vitamin” injections at a weight loss clinic. Now I’m like “oh, yeah, makes sense.”

When a mid-50s woman who has been overweight her whole life starts losing weight at a rapid pace you kinda know it’s not completely without help.

And she told you that because she knows what a nasty judgmental person you are. Why do you care how someone loses weight? Why do you even care that they are losing weight? None of your business, weirdo.

[Anonymous]

There are definitely side effects but you have to weigh the pros/cons and assess which is worse. There are no magic pills so do realize that you will pay for it one way or another

My dad was prediabetic and on Ozempic for a few years. He lost a ton of weight but stopped when copay went up due to the popularity of drug. As a result, he developed serious gastrointestinal problems when eating and something akin to IBS (these drugs slow your metabolism so it’s hard to reboot when you stop). He started taking pain meds and treatment for that. He eventually normalized but did gain most weight back

But if you’re looking at morbid obesity, it is likely something you’ll take for life