RE Recommendations for Repeated Miscarriage
![[Post New]](/jforum/templates/default/images/icon_minipost_new.gif){kind=icon}
Anonymous
| I am picking your brain, all. Went through IF with a friend--I eventually found a protocol that worked and am on the other side. Meanwhile my friend has had 4 miscarriages and 9 transfers. She did immune treatments and a tried a surrogate (surrogate has a mc at the same time as all the other mc my friend has had). It could be genetic but I doubt it is placental or uterine at this point given that the surrogate also had a mc (two transfers). Can anyone recommend an RE who is just a stellar person with really tough cases, particularly repeated miscarriage? Also, anyone have an idea of what might be at play here? She makes a lot of embies and a lot of PGS normal ones as well! (Yes, they are tested!) |
Anonymous
| Dr Peters SIRM in NJ and PA |
Anonymous
| Dr. Wang, Dr. Tortoriello at SIRM - NY (thing wang is in Westchester now) |
Anonymous
|
Is her surrogate a family member? I think maybe try a different surrogate. Why do you think it isn't genetic? Are these pgs tested embryos?
Dr. Braverman is the best for any repeat losses |
Anonymous
Surrogate was a non-family member. We think it is genetic because the embies in both uterine environments arrest at the same time. At least half of the 9 transfers and the surrogate transfers (two transfers) were pgs tested embies and the miscarriages were tested after the fact (3 of 4 miscarriage were normal embies; one was Turners if I remember correctly). She also tried two rounds of immune protocols with a reputable doctor (not Braverman though), |
Anonymous
also, thanks for the suggestions! Keep them coming!  And I will take all and any ideas!
|
Anonymous
| Is she using OE and DH's sperm? I don't know much about it, but I think there can be something related to maternal mitrochondrial DNA, which I don't think would show up in PGS. I have no idea where I heard that or who could help with it, but it might be something worth looking into (or DE itself might be something to try). |
Anonymous
| Each was with OE and DH's sperm. They did all the routine genetic testing they put one person through pre-IVF. You all remember that--the counsyl. So they aren't CF carriers. I did wonder about balanced translocation, but I am pretty sure they tested for it. A DE might be an option. She has 11 embies though. She makes eggs like a frog (we joke) and they all fertilize and grow to blast. They just all arrest before week 8. |
Anonymous
Do you know what immune treatments she tried and who with? |
Anonymous
| She did two cycles with Dr. KK--IVIg and pred were used. |
Anonymous
| IVIG didn't work for me either but Neupogen did. I still think Dr. Braverman would be the next logical step. He has access to different tests and could see if there is an HLA issue with lack of mismatches. |
Anonymous
Do you know what you had? That Neupogen helped with? Also, did you do Neupogen shots or washes? |
Anonymous
| i had a combination of stuff, clotting, genetic HLA compatibility issues and KIR, elevated TNF. My Tregs were low and the Neupogen helped created a more tolerant environment for implantation. There is also a patent out there for using G-CSF for recurrent losses and also preE. Dr. Darryl Carter's name is on the patent in conjunction with Nora Therapeutics. I just did the injections. I used the vials and measured out the dosage based on weight. Dosages Dr. Braverman uses are in conjunction with the Scarpellini study. |
Anonymous
| Wanted to add that reading the study and the patent really convinced me to try the treatment. Plus, neutropenic women have been using this treatment for decades without ill effect to themselves or their babies. Even with the high cost of meds it was cheaper than a gestational surrogate. |
Anonymous
| Neutropenic? Can you tell me more? This is helpful! Thank you! |