Able to get pregnant, unable to stay pregnant

[Anonymous]

I am able to get pregnant but each pregnancy has resulted in a miscarriage. They suspect bad genetic luck as each yolk sac has appeared enlarged prior to miscarriage. I am currently about to miscarry again after losing the heartbeat and will finally get this tissue tested to get some more definitive answers.

Has anyone with a similar story had success with IVF and PGT? We were told this would be our next step to reduce the changes of poor genetics to occur again. Other lab work has gone back normal for the usual suspects (thyroid, blood clotting disorders, sperm quality etc.) .

[Anonymous]

*come back normal (sorry spelling)

[Anonymous]

No advice but just wanted to say I completely understand.

I had 5 losses before finally conceiving my now 20 month old son. He was born 6 weeks early due to me developing preeclampsia. I had a c section and my placenta was sent to pathology and SO many things came back that were bad with my placenta. My Dr said it’s actually a miracle my son lasted until 34 weeks with all the issues with my placenta and we now wonder if all my losses were due to placenta issues. We are currently TTC #2 and I’ve again had 3 losses in a row (chemical, blighted ovum + another chemical). So I can get pregnant but again, keep losing the pregnancies.

[Anonymous]

No I also lost the IVF baby.

I wish when I was in your position someone had told me about reproductive immunologists. He found my issues and is treating them.

[Anonymous]

Anonymous wrote:No advice but just wanted to say I completely understand.

I had 5 losses before finally conceiving my now 20 month old son. He was born 6 weeks early due to me developing preeclampsia. I had a c section and my placenta was sent to pathology and SO many things came back that were bad with my placenta. My Dr said it’s actually a miracle my son lasted until 34 weeks with all the issues with my placenta and we now wonder if all my losses were due to placenta issues. We are currently TTC #2 and I’ve again had 3 losses in a row (chemical, blighted ovum + another chemical). So I can get pregnant but again, keep losing the pregnancies.

You most likely have immunology issues. The preE and bad placenta are all signs that your immune system is attacking the pregnancy.

[Anonymous]

When you say yolk sac is enlarged, is it misshapen? Have you had the antiphospholipid test done?

[Anonymous]

Never mind, I just read that your blood clotting disorder tests came back fine.

[Anonymous]

Anonymous wrote:Never mind, I just read that your blood clotting disorder tests came back fine.

I'm the PP that lost my IVF baby too - I had a rare blood clotting disorder not on the standard panels, so there are other possible causes.

[Anonymous]

Anonymous wrote:When you say yolk sac is enlarged, is it misshapen? Have you had the antiphospholipid test done?

Yes sac was enlarged and misshapen. I am waiting for POC to get tested. I tested negative for APL

[Anonymous]

Anonymous wrote:

Anonymous wrote:No advice but just wanted to say I completely understand.

I had 5 losses before finally conceiving my now 20 month old son. He was born 6 weeks early due to me developing preeclampsia. I had a c section and my placenta was sent to pathology and SO many things came back that were bad with my placenta. My Dr said it’s actually a miracle my son lasted until 34 weeks with all the issues with my placenta and we now wonder if all my losses were due to placenta issues. We are currently TTC #2 and I’ve again had 3 losses in a row (chemical, blighted ovum + another chemical). So I can get pregnant but again, keep losing the pregnancies.

You most likely have immunology issues. The preE and bad placenta are all signs that your immune system is attacking the pregnancy.

yes this! See a reproductive immunologist. I had severe pre-E with my first at 29 weeks. Lost three more babies (1 ectopic and 2 early miscarriages of genetically normal babies even while on lovenox because of blood clotting disorder) and my tubes and had a number of failed IVF transfers (1 of a top graded genetically normal embryo). Went to see reproductive immunologist and had all the tests done. Yup, immune issues. Number 2 has been an epic ordeal for me too.

[Anonymous]

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:No advice but just wanted to say I completely understand.

I had 5 losses before finally conceiving my now 20 month old son. He was born 6 weeks early due to me developing preeclampsia. I had a c section and my placenta was sent to pathology and SO many things came back that were bad with my placenta. My Dr said it’s actually a miracle my son lasted until 34 weeks with all the issues with my placenta and we now wonder if all my losses were due to placenta issues. We are currently TTC #2 and I’ve again had 3 losses in a row (chemical, blighted ovum + another chemical). So I can get pregnant but again, keep losing the pregnancies.

You most likely have immunology issues. The preE and bad placenta are all signs that your immune system is attacking the pregnancy.

yes this! See a reproductive immunologist. I had severe pre-E with my first at 29 weeks. Lost three more babies (1 ectopic and 2 early miscarriages of genetically normal babies even while on lovenox because of blood clotting disorder) and my tubes and had a number of failed IVF transfers (1 of a top graded genetically normal embryo). Went to see reproductive immunologist and had all the tests done. Yup, immune issues. Number 2 has been an epic ordeal for me too.

I’m sorry to hear this. What treatment have they recommended now for number 2?

[Anonymous]

Get checked for a uterine infection too.

[Anonymous]

Anonymous wrote:Get checked for a uterine infection too.

Thank you! Yes, I am waiting for my cycle to return and then they will schedule a biopsy to check for endometriosis.

[Anonymous]

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:No advice but just wanted to say I completely understand.

I had 5 losses before finally conceiving my now 20 month old son. He was born 6 weeks early due to me developing preeclampsia. I had a c section and my placenta was sent to pathology and SO many things came back that were bad with my placenta. My Dr said it’s actually a miracle my son lasted until 34 weeks with all the issues with my placenta and we now wonder if all my losses were due to placenta issues. We are currently TTC #2 and I’ve again had 3 losses in a row (chemical, blighted ovum + another chemical). So I can get pregnant but again, keep losing the pregnancies.

You most likely have immunology issues. The preE and bad placenta are all signs that your immune system is attacking the pregnancy.

yes this! See a reproductive immunologist. I had severe pre-E with my first at 29 weeks. Lost three more babies (1 ectopic and 2 early miscarriages of genetically normal babies even while on lovenox because of blood clotting disorder) and my tubes and had a number of failed IVF transfers (1 of a top graded genetically normal embryo). Went to see reproductive immunologist and had all the tests done. Yup, immune issues. Number 2 has been an epic ordeal for me too.

I’m sorry to hear this. What treatment have they recommended now for number 2?

Predisnone, baby aspirin, lovenox, plaquenil, and IVIG

[Anonymous]

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:No advice but just wanted to say I completely understand.

I had 5 losses before finally conceiving my now 20 month old son. He was born 6 weeks early due to me developing preeclampsia. I had a c section and my placenta was sent to pathology and SO many things came back that were bad with my placenta. My Dr said it’s actually a miracle my son lasted until 34 weeks with all the issues with my placenta and we now wonder if all my losses were due to placenta issues. We are currently TTC #2 and I’ve again had 3 losses in a row (chemical, blighted ovum + another chemical). So I can get pregnant but again, keep losing the pregnancies.

You most likely have immunology issues. The preE and bad placenta are all signs that your immune system is attacking the pregnancy.

yes this! See a reproductive immunologist. I had severe pre-E with my first at 29 weeks. Lost three more babies (1 ectopic and 2 early miscarriages of genetically normal babies even while on lovenox because of blood clotting disorder) and my tubes and had a number of failed IVF transfers (1 of a top graded genetically normal embryo). Went to see reproductive immunologist and had all the tests done. Yup, immune issues. Number 2 has been an epic ordeal for me too.

I’m sorry to hear this. What treatment have they recommended now for number 2?

Predisnone, baby aspirin, lovenox, plaquenil, and IVIG

So you have lupus?